{"id":9578,"date":"2023-03-27T12:18:28","date_gmt":"2023-03-27T18:18:28","guid":{"rendered":"https:\/\/nuevo22.cidsamexico.com\/?post_type=al_product&p=9578"},"modified":"2023-03-27T14:29:22","modified_gmt":"2023-03-27T20:29:22","slug":"proteina-ntsr1","status":"publish","type":"al_product","link":"https:\/\/nuevo22.cidsamexico.com\/index.php\/productos\/proteina-ntsr1\/","title":{"rendered":"Proteina NTSR1"},"content":{"rendered":"\n

Las prote\u00ednas de membrana son la clase de prote\u00ednas m\u00e1s relevante desde el punto de vista farmac\u00e9utico. Al mismo tiempo, es muy dif\u00edcil obtenerlos en forma pura y activa. Los expertos en prote\u00ednas de Cube Biotech han trabajado arduamente para producir GPCR humanos con la calidad suficiente que ahora podemos ofrecer a la comunidad. <\/p>\n\n\n\n

Ofrecemos NTSR1 activo, un GPCR humano que se une al neurotransmisor neurotensina. La prote\u00edna est\u00e1 disponible lista para usar, lista para estudios de uni\u00f3n de ligandos, cristalizaci\u00f3n y otros experimentos bioqu\u00edmicos\/biof\u00edsicos. P\u00f3ngase en contacto con nosotros para consultas masivas, proyectos acad\u00e9micos o ideas de colaboraci\u00f3n.<\/p>\n\n\n\n

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Catalogo<\/th>Producto<\/th>Presentaci\u00f3n<\/th><\/tr><\/thead>
CU-28301<\/td>Proteina NTSR1<\/td>10 ug<\/td><\/tr>
CU-28303<\/td>Proteina NTSR1<\/td>50 ug<\/td><\/tr>
CU-28304<\/td>Proteina NTSR1<\/td>100 ug<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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\"pdf\"\/<\/figure>\n\n\n\n

Datasheet NTSR1<\/a><\/p>\n<\/div>\n\n\n\n

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Caracteristicas<\/mark><\/p>\n\n\n\n

<\/th><\/th><\/tr>
Alternative names<\/td>High-affinity levocabastine-insensitive neurotensin receptor NTRH<\/td><\/tr>
UniProt Number<\/td>P30989<\/a><\/td><\/tr>
Protein class<\/td>GPCR<\/td><\/tr>
Organism<\/td>Human (Homo sapiens)<\/em><\/td><\/tr>
Sequence, explained<\/td>Full-length, wildtype sequence N-terminal HA-tag, 6x His-tag, spacer, Rho1D4-tag<\/td><\/tr>
Sequence, One-Letter Code<\/td>MKTIIALSYIFCLVFAHHHHHHRLNSSAPGT PGTPAADPFQ RAQAGLEEAL LAPGFGNASG NASERVLAAP SSELDVNTDI YSKVLVTAVY LALFVVGTVG NTVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLTLLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVVIQVN TFMSFIFPMV VISVLNTIIA NKLTVMVRQA AEQGQVCTVG GEHSTFSMAI EPGRVQALRH GVRVLRAVVI AFVVCWLPYH VRRLMFCYIS DEQWTPFLYD FYHYFYMVTN ALFYVSSTIN PILYNLVSAN FRHIFLATLA CLCPVWRRRR KRPAFSRKAD SVSSNHTLSS NATRETLYGSSGTETSQVAPA<\/td><\/tr>
Affinity tags<\/td>N-terminal His-tag \/ C-terminal Rho1D4-tag<\/td><\/tr>
Expression Host<\/td>Sf9 (baculovirus)<\/td><\/tr>
Size (excluding additional elements)<\/td>436 amino acids, 48,13 kDa<\/td><\/tr>
Buffer composition<\/td>50 mM HEPES, pH 8.0; 200 mM NaCl; 10% Glycerol; 0.1% n-Decyl-beta-maltoside; 0.01% cholesterolhemisuccinate; 0.01% CHAPS<\/td><\/tr>
Purity<\/td>>95%, determined via SDS-PAGE<\/td><\/tr>
Purified via<\/td>Rho1D4-tag affinity chromatography, followed by size exclusion chromatography<\/td><\/tr>
Homogeneity<\/td>Size exclusion chromatography<\/td><\/tr>
Activity<\/td>Not determined<\/em><\/td><\/tr>
Function<\/td>Receptor for neurotensin. Involved in hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
<\/div>\n\n\n\n

Funci\u00f3n<\/mark><\/p>\n\n\n\n

Receptor de neurotensina. Participa en hipotensi\u00f3n, hiperglucemia, hipotermia,
antinocicepci\u00f3n y regulaci\u00f3n de la motilidad y secreci\u00f3n intestinal.<\/p>\n\n\n\n

<\/div>\n\n\n\n

Control de Calidad<\/mark>
Pureza: (SDS-PAGE) >95% de acuerdo a lo determinado por SDS-PAGE, ver Fig. 1
Homogeneidad: Tama\u00f1o exclusi\u00f3n a cromatograf\u00eda
Actividad: No determinado<\/p>\n\n\n\n

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Aplicaciones<\/mark>
\u2022 SDS-PAGE
\u2022 Western Blot
\u2022 Protein Crystallization
\u2022 Biochemical and biophysical analyses<\/p>\n\n\n\n

\u2022 Ligand binding assays (e.g. SPR)<\/p>\n\n\n\n

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Envio y Almacenamiento<\/mark><\/p>\n\n\n\n

Este producto se envia en hielo seco y se almacena a -80\u00b0C. Evitar los ciclos de congelaci\u00f3n y descongelaci\u00f3n. <\/p>\n\n\n\n

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Descargo de responsabilidad<\/mark>:<\/strong> Nuestros productos est\u00e1n destinados para investigacion en aplicaciones de biolog\u00eda molecular. Estos productos no est\u00e1n destinados al diagn\u00f3stico, prevenci\u00f3n o tratamiento de una enfermedad.<\/p>\n\n\n\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Proteina de Cube Biotech<\/p>\n","protected":false},"featured_media":9579,"template":"","al_product-cat":[39,34],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product\/9578"}],"collection":[{"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product"}],"about":[{"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/types\/al_product"}],"version-history":[{"count":2,"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product\/9578\/revisions"}],"predecessor-version":[{"id":9599,"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product\/9578\/revisions\/9599"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/media\/9579"}],"wp:attachment":[{"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/media?parent=9578"}],"wp:term":[{"taxonomy":"al_product-cat","embeddable":true,"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product-cat?post=9578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}