{"id":11500,"date":"2023-04-28T19:18:36","date_gmt":"2023-04-29T00:18:36","guid":{"rendered":"https:\/\/nuevo22.cidsamexico.com\/?post_type=al_product&p=11500"},"modified":"2023-04-28T19:37:45","modified_gmt":"2023-04-29T00:37:45","slug":"indicador-thallos-am","status":"publish","type":"al_product","link":"https:\/\/nuevo22.cidsamexico.com\/index.php\/productos\/indicador-thallos-am\/","title":{"rendered":"Indicador Thallos AM"},"content":{"rendered":"\n

El mejor de su clase, fluorescente verde, indicador de talio (Tl\u207a), permeable a la membrana. Funciona con potasio (K\u207a), sodio (Na\u207a) y canales de cationes monovalentes y transportadores.<\/p>\n\n\n\n

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Catalogo<\/th>Producto<\/th>Presentaci\u00f3n<\/th><\/tr><\/thead>
ON-1381<\/td>Thallos AM<\/td>3 x 50 ug<\/td><\/tr>
ON-1381C<\/td>Thallos AM<\/td>10 x 50 ug<\/td><\/tr>
ON-1381F<\/td>Thallos AM<\/td>500 ug<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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Protocolo<\/a><\/p>\n\n\n\n

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Especificaciones<\/a><\/p>\n\n\n\n

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SDS<\/a><\/p>\n<\/div>\n\n\n\n

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Especificaciones<\/strong><\/mark><\/p>\n\n\n\n

Excitaci\u00f3n<\/td>490 nm\u00a0\"\"\u00a0<\/a><\/td><\/tr>
Emisi\u00f3n<\/td>515 nm\u00a0\"\" <\/a><\/td><\/tr>
Solubilidad<\/td>DMSO<\/td><\/tr>
Peso molecular<\/td>840 g\/mol<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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Thallos es un indicador de talio intracelular (Tl\u207a) fluorescente verde y ha sido el est\u00e1ndar de oro para HTS de canal de potasio (K\u207a) basado en fluorescencia durante casi 2 d\u00e9cadas. Thallos tambi\u00e9n ofrece resultados sobresalientes para una amplia variedad de canales, transportadores y GPCR de cationes monovalentes (sodio \u2013 Na\u207a).<\/p>\n\n\n\n

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Productos Relacionados<\/strong><\/mark><\/p>\n\n\n\n

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Brilliant Thallium Gold<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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Brilliant Thallium Express<\/figcaption><\/figure>\n<\/div>\n\n\n\n
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Thallios Gold<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n
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Referencias<\/mark><\/p>\n\n\n\n

Weaver CD, Harden D, Dworetzky SI, Robertson B, Knox RJ. A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells. J Biomol Screen. 2004 Dec;9(8):671-7. doi: 10.1177\/1087057104268749<\/a><\/p>\n\n\n\n


Weaver CD. Thallium Flux Assay for Measuring the Activity of Monovalent Cation Channels and Transporters. Methods Mol Biol. 2018;1684:105-114. doi: 10.1007\/978-1-4939-7362-0_9<\/a><\/p>\n\n\n\n

Carmosino M, Rizzo F, Torretta S, Procino G, Svelto M. High-throughput fluorescent-based NKCC functional assay in adherent epithelial cells. BMC Cell Biol. 2013 Mar 18;14:16. doi: 10.1186\/1471-2121-14-16<\/a><\/p>\n\n\n\n

Du Y, Days E, Romaine I, Abney KK, Kaufmann K, Sulikowski G, Stauffer S, Lindsley CW, Weaver CD. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. ACS Chem Neurosci. 2015 Jun 17;6(6):871-8. doi: 10.1021\/acschemneuro.5b0000<\/a><\/p>\n\n\n\n

Zhang D, Gopalakrishnan SM, Freiberg G, Surowy CS. A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. J Biomol Screen. 2010 Feb;15(2):177-84. doi: 10.1177\/1087057109355708<\/a><\/p>\n\n\n\n

Niswender CM, Johnson KA, Luo Q, Ayala JE, Kim C, Conn PJ, Weaver CD. A novel assay of Gi\/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors. Mol Pharmacol. 2008 Apr;73(4):1213-24. doi: 10.1124\/mol.107.041053<\/a><\/p>\n\n\n\n

Delpire E, Days E, Lewis LM, Mi D, Kim K, Lindsley CW, Weaver CD. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. doi: 10.1073\/pnas.0812756106<\/a><\/p>\n\n\n\n

Schmalhofer WA, Swensen AM, Thomas BS, Felix JP, Haedo RJ, Solly K, Kiss L, Kaczorowski GJ, Garcia ML. A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-\u00e0-go-go related gene potassium channel. Assay Drug Dev Technol. 2010 Dec;8(6):714-26. doi: 10.1089\/adt.2010.0351<\/a><\/p>\n\n\n\n

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Garantia ON Assurance. La calidad de este producto esta garantizado. Si no est\u00e1 satisfecho con su pedido, trabajaremos para resolver de inmediato su inquietud de acuerdo con nuestros t\u00e9rminos y condiciones de ION Assurance.<\/p>\n\n\n\n

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Indicador de talio intracelular (Tl\u207a) fluorescente verde y ha sido el est\u00e1ndar de oro para HTS de canal de potasio (K\u207a) basado en fluorescencia.<\/p>\n","protected":false},"featured_media":11506,"template":"","al_product-cat":[34],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product\/11500"}],"collection":[{"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product"}],"about":[{"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/types\/al_product"}],"version-history":[{"count":2,"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product\/11500\/revisions"}],"predecessor-version":[{"id":11508,"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product\/11500\/revisions\/11508"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/media\/11506"}],"wp:attachment":[{"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/media?parent=11500"}],"wp:term":[{"taxonomy":"al_product-cat","embeddable":true,"href":"https:\/\/nuevo22.cidsamexico.com\/index.php\/wp-json\/wp\/v2\/al_product-cat?post=11500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}